Postdoctoral Researcher - 11954BR

Postdoctoral Researcher

Medicinal Chemistry
University of Kansas - Lawrence
Employee Class: 
U-Unclassified Professional Staff

Position Overview

This position is available at the University of Kansas, Lawrence. Research projects will be held in the laboratory of Professor Michael Wolfe. Successful candidates will conduct research on protease biochemistry, biophysics, and molecular biology, specifically the study of intramembrane proteases such as gamma-secretase. Mutations in this membrane protease complex cause hereditary early-onset Alzheimer’s disease. The position will involve elucidation of substrate recognition and enzyme mechanisms and how these are altered by Alzheimer-causing mutations. The position may also involve the study of related intramembrane proteases.

Job Description

Designing and execution of experiments (60%)-
  • These duties include carrying out original research relative to the mission of the Wolfe laboratory. The lab is focused on the mechanism and pharmacological modulation of intramembrane proteases such as gamma-secretase and understanding the pathogenesis of Alzheimer’s disease. The successful applicant will design and execute experiments that pertain to current research topics in the laboratory. Laboratory techniques will include cloning and mutagenesis, protein expression and purification, enzyme and cell-based assays, and testing new inhibitors and substrates.
Write reports and papers (20%)-
  • These duties include writing technical internal reports, standard protocols developed in the lab, and scientific papers for peer reviewed journals.
Assist other lab and department members with experiments (10%)-
  • Trains other staff in the use of specialized equipment as well coordinates the maintenance of laboratory equipment.
Routine lab management (10%) –
  • These duties include but are not limited to ensuring systems are in place for efficient planning of lab supplies, management of laboratory records and documents as well as experimental protocols and data, and coordination of good lab practices and lab safety.

Required Qualifications

  • Ph.D. in the area of protein biochemistry or biophysics or a related field.
  • Experience in the design, execution, and interpretation of relevant experiments using protein expression, purification and assays
  • Experience in the design, execution, and interpretation of relevant experiments using molecular biology (e.g., mutagenesis)
  • Excellent written communication skills as demonstrated in application materials and publications.

Preferred Qualifications

  • Experience in membrane protein biochemistry
  • Experience with biophysical techniques such as SPR, ITC and CD.
  • Broad knowledge of cell and molecular biology.
  • Publications in the areas of biochemistry, biophysics and/or cell and molecular biology.
  • Demonstrated ability to work successfully as part of a collaborative research effort.

Additional Candidate Instructions

A complete application includes: an online application, cover letter, resume, and contact information for three professional references. The cover letter and resume should clearly indicate how you meet the required and preferred qualifications. Review of applications begins July 23, 2018 and continues until a qualified pool of applicants has been identified.

Contact Information to Applicants

Professor Michael Wolfe

Advertised Salary Range

NIH level, commensurate with experience

Application Review Begins


Search Jobs
Posting Information
Posting ID:
Medicinal Chemistry
University of Kansas - Lawrence
Employee Class:
U-Unclassified Professional Staff
Application Review Begins:
One of 34 U.S. public institutions in the prestigious Association of American Universities
44 nationally ranked graduate programs.
—U.S. News & World Report
Top 50 nationwide for size of library collection.
23rd nationwide for service to veterans —"Best for Vets," Military Times
KU Today