Postdoctoral Researcher - 22234BR

Postdoctoral Researcher

Department: 
Medicinal Chemistry
Location/Division: 
University of Kansas Lawrence Campus
Work Location Assignment: 
On-Site
Reg/Temp: 
Regular
Employee Class: 
U-Unclassified Professional Staff

Position Overview

This position is available at the University of Kansas, Lawrence. Research projects will be held in the laboratory of Professor Michael Wolfe. Successful candidates will conduct research on protease biochemistry, biophysics, and molecular biology, specifically the study of the intramembrane protease gamma-secretase. This position will involve elucidation of substrate recognition and enzyme mechanisms and how these are altered by Alzheimer-causing mutations.

Job Description

60% - Designing and execution of experiments
  • These duties include carrying out original research relative to the mission of the Wolfe laboratory. The lab is focused on the mechanism and pharmacological modulation of the intramembrane protease gamma-secretase and understanding the pathogenesis of Alzheimer's disease. The successful applicant will design and execute experiments that pertain to current research topics in the laboratory. Laboratory techniques will include cloning and mutagenesis, protein expression/purification/characterization, enzyme and cell-based assays, mass spectrometry, and testing new inhibitors and substrates.
20% - Write reports and papers
  • These duties include writing technical internal reports, standard protocols developed in the lab and scientific papers for peer reviewed journals.
10% - Assist other center members with experiments
  • Trains other staff in the use of specialized equipment as well as coordinates the maintenance of laboratory equipment.
10% - Routine lab management
  • These duties include but are note limited to ensuring systems are in place for efficient planning of lab supplies, management of laboratory records and documents as well as experimental protocols and data, and coordination of good lab practices and lab safety.

Required Qualifications

1. PhD in the area of protein biochemistry, biophysics, or closely related field.
2. Experience and design of relevant experiments using protein expression, purification and assays, as demonstrated by a minimum of 2 publications.
3. Experience and design of relevant experiments using molecular biology (e.g., mutagenesis), as demonstrated by a minimum of 2 publications.
4. Knowledgeable on the use of mass spectrometry for protein and peptide analysis.
5. Excellent written communication skills as demonstrated in application materials and publications.

Preferred Qualifications

1. Experience in membrane protein biochemistry.
2. Experience with biophysical techniques for protein analysis (e.g., fluorescence polarization)
3. Broad knowledge of cell and molecular biology.
4. Publications in the areas of biochemistry, biophysics and/or cell and molecular biology.
5. Demonstrated ability to work successfully as part of a collaborative effort.

Additional Candidate Instructions

A complete application includes: an online application, cover letter, resume and contact information for three professional references. The cover letter and resume should clearly indicate you meet the required and preferred qualifications. Incomplete applications will not be considered.

Application review begins May 31, 2022 and continues until a successful candidate has been identified. To ensure first consideration, please apply by May 30, 2022.

Contact Information to Applicants

Dr. Michael Wolfe
mswolfe@ku.edu

Advertised Salary Range

53,000 - 58,000 - Commensurate with exoerience

Application Review Begins

31-May-2022

Anticipated Start Date

01-Jul-2022

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Posting Information
Posting ID:
22234BR
Department:
Medicinal Chemistry
Primary Campus:
University of Kansas Lawrence Campus
Work Location Assignment:
On-Site
Reg/Temp:
Regular
Employee Class:
U-Unclassified Professional Staff
Application Review Begins:
31-May-2022